Core route · step 18/21 · source T02

主路线 · 第 18/21 步 · 来源 T02

Activation

激活

Source: supplied project-theory book, Stage 2. The complete bilingual chapter follows, with its derivations and qualifications. Textbook source (Markdown) · Original Markdown.

来源:所给项目理论教材阶段 2。下方完整收录双语章节及推导和限定。教材原文(Markdown) · 原始 Markdown。

Keep the source’s evidence states: optical normalization is an accounting check; activation is uncalibrated; R(t) is prescribed; near-wall loading and cohesive release remain conditional.

保留来源证据状态:光学归一化属于核算检查;激活尚未标定;R(t) 为规定输入;近壁加载及黏聚释放仍有条件。

2. Activation2.1 Why use a logistic model?2.2 From one droplet to many droplets2.3 Adding the detector

2. Activation

激活

From local heating to the probability of an event. Corresponding to Theory 02, source page 2.

从局部加热到事件发生概率。对应 Theory 02,原始材料第2页。

The source does not supply a thermodynamic nucleation-barrier model. Instead, it introduces an empirical, conditioned probability model. Its functional form can be explained mathematically, but its coefficients cannot be derived from energy conservation.

原始材料没有提供热力学成核势垒模型,而是引入了一个经验性的条件概率模型。可以从数学上解释其函数形式,但无法由能量守恒推导出其系数。

2.1 Why use a logistic model?

为什么使用逻辑概率模型?

Let p1p_1 be the probability of an event associated with one available droplet. A probability must satisfy

以 p1p_1 表示一个可参与激活的液滴发生事件的概率。概率必须满足

0≤p1≤1.0\le p_1\le1.
2.1 Why use a logistic model? / 为什么使用逻辑概率模型?; p_1: single-droplet true-event probability

The diagram locates the physical system; its key lists the symbols in the formula. Read the definition in the surrounding derivation when a letter has different roles.

图示标出物理体系,图例列出公式中的符号。若某字母有多种作用,应以邻近推导中的定义为准。

A linear expression in dose and other variables does not automatically respect those bounds. The logistic construction instead makes the logarithm of the odds linear:

直接将剂量和其他变量线性相加,并不能自动满足这些取值范围。逻辑模型转而将优势比的对数设为线性形式:

logit⁡(p1)=ln⁡(p11−p1)=ℓ.\operatorname{logit}(p_1)=\ln\left(\frac{p_1}{1-p_1}\right)=\ell.
2.1 Why use a logistic model? / 为什么使用逻辑概率模型?; p_1: single-droplet true-event probability; ℓ: logit / specified length

The diagram locates the physical system; its key lists the symbols in the formula. Read the definition in the surrounding derivation when a letter has different roles.

图示标出物理体系,图例列出公式中的符号。若某字母有多种作用,应以邻近推导中的定义为准。

Solving,

求解得到

p11−p1=eℓ⟹p1=11+e−ℓ.\frac{p_1}{1-p_1}=e^\ell\quad\Longrightarrow\quad\boxed{p_1=\frac{1}{1+e^{-\ell}}}.
2.1 Why use a logistic model? / 为什么使用逻辑概率模型?; p_1: single-droplet true-event probability; ℓ: absorption / cohesive-zone length

The diagram locates the physical system; its key lists the symbols in the formula. Read the definition in the surrounding derivation when a letter has different roles.

图示标出物理体系,图例列出公式中的符号。若某字母有多种作用,应以邻近推导中的定义为准。

The source writes the predictor in the form

原始材料将预测量写成如下形式:

ℓ=β0+bbatch+βDln⁡DabsDref+βQln⁡q˙max⁡′′′q˙ref′′′+βτln⁡τLτref+fa(ad)+zformTβform+zdetTβdet+zhistTβhist.\begin{aligned} \ell={}&\beta_0+b_{\mathrm{batch}} +\beta_D\ln\frac{D_{\mathrm{abs}}}{D_{\mathrm{ref}}} +\beta_Q\ln\frac{\dot q'''_{\max}}{\dot q'''_{\mathrm{ref}}}\\ &+\beta_\tau\ln\frac{\tau_L}{\tau_{\mathrm{ref}}} +f_a(a_d) +\mathbf z_{\mathrm{form}}^T\boldsymbol\beta_{\mathrm{form}}\\ &+\mathbf z_{\mathrm{det}}^T\boldsymbol\beta_{\mathrm{det}} +\mathbf z_{\mathrm{hist}}^T\boldsymbol\beta_{\mathrm{hist}}. \end{aligned}
2.1 Why use a logistic model? / 为什么使用逻辑概率模型?; ℓ: logit / specified length; β_0: activation regression coefficient; b_batch: spatial profile / batch effect; β_D: activation regression coefficient; D_abs: absorbed dose per unit volume; D_ref: reference absorbed dose; β_Q: activation regression coefficient; q̇'''_max: peak volumetric deposition rate; q̇'''_ref: peak volumetric deposition rate; β_τ: activation regression coefficient; τ_L: laser pulse FWHM; τ_ref: duration / dimensionless time / dummy time; f_a: frequency / predictor / false detections; a_d: droplet radius / film span / acceleration; z_form: depth / formulation predictor; T: temperature / kinetic energy as defined; β_form: activation regression coefficient; z_det: depth / formulation predictor; β_det: activation regression coefficient; z_hist: depth / formulation predictor; β_hist: activation regression coefficient

The diagram locates the physical system; its key lists the symbols in the formula. Read the definition in the surrounding derivation when a letter has different roles.

图示标出物理体系,图例列出公式中的符号。若某字母有多种作用,应以邻近推导中的定义为准。

Here ada_d denotes droplet size. The remaining terms account for formulation, batch, detector state, and pulse history. The reference quantities make logarithm arguments dimensionless. None of these coefficients is calibrated in the supplied theory pages. [S1, p. 2]

这里的 ada_d 表示液滴尺寸。其余各项用于考虑配方、批次、探测器状态和脉冲历史。参考量的作用是使对数中的自变量无量纲化。所提供的理论页面中,这些系数均尚未标定。 [S1,第2页]

There is a useful algebraic subtlety. For the exact Gaussian pulse model above,

这里有一个值得注意的代数细节。对于前面给出的精确高斯脉冲模型,

ln⁡q˙max⁡′′′=ln⁡Dabs−ln⁡τL+constant.\ln\dot q'''_{\max}=\ln D_{\mathrm{abs}}-\ln\tau_L+\text{constant}.
2.1 Why use a logistic model? / 为什么使用逻辑概率模型?; q̇'''_max: peak volumetric deposition rate; D_abs: absorbed dose per unit volume; τ_L: laser pulse FWHM

The diagram locates the physical system; its key lists the symbols in the formula. Read the definition in the surrounding derivation when a letter has different roles.

图示标出物理体系,图例列出公式中的符号。若某字母有多种作用,应以邻近推导中的定义为准。

Therefore dose, peak rate, and pulse width are not three independent predictors within that restricted pulse family. Their separate coefficients require an identifiable parameterization or additional experimental structure. This follows directly from the source equations; it is not a calibrated result.

因此,在这一受限的脉冲族中,剂量、峰值速率和脉宽并不是三个相互独立的预测量。要分别识别它们的系数,需要采用具有可辨识性的参数化方式,或提供额外的实验设计信息。这是由热源方程直接得到的结论,并非标定结果。

Also, because the slide includes detector-state covariates inside the logit, the fitted model should not automatically be interpreted as an intrinsic, detector-independent material law.

此外,由于原始页面将探测器状态协变量直接放入 logit 表达式中,因此不能自动将拟合得到的模型解释为独立于探测器的材料内禀规律。

2.2 From one droplet to many droplets

从单个液滴到液滴群体

Suppose there are NactiveN_{\mathrm{active}} available droplets, with independent events and equal probability p1p_1.

假设有 NactiveN_{\mathrm{active}} 个可参与激活的液滴,各液滴的事件彼此独立,且事件概率均为 p1p_1。

For one droplet,

对于一个液滴,

P(no event)=1−p1.P(\text{no event})=1-p_1.
2.2 From one droplet to many droplets / 从单个液滴到液滴群体; P: event probability; p_1: single-droplet true-event probability

The diagram locates the physical system; its key lists the symbols in the formula. Read the definition in the surrounding derivation when a letter has different roles.

图示标出物理体系,图例列出公式中的符号。若某字母有多种作用,应以邻近推导中的定义为准。

Independence gives

由独立性可得

P(no events among all droplets)=(1−p1)Nactive.P(\text{no events among all droplets})=(1-p_1)^{N_{\mathrm{active}}}.
2.2 From one droplet to many droplets / 从单个液滴到液滴群体; P: event probability; p_1: single-droplet true-event probability; N_active: event count / membrane tension

The diagram locates the physical system; its key lists the symbols in the formula. Read the definition in the surrounding derivation when a letter has different roles.

图示标出物理体系,图例列出公式中的符号。若某字母有多种作用,应以邻近推导中的定义为准。

Taking the complement,

取其补事件,得到

P≥1(N)=1−(1−p1)Nactive.\boxed{P_{\ge1}^{(N)}=1-(1-p_1)^{N_{\mathrm{active}}}}.
2.2 From one droplet to many droplets / 从单个液滴到液滴群体; P_ge1: at least one true event; N: event count / membrane tension; p_1: single-droplet true-event probability; N_active: event count / membrane tension

The diagram locates the physical system; its key lists the symbols in the formula. Read the definition in the surrounding derivation when a letter has different roles.

图示标出物理体系,图例列出公式中的符号。若某字母有多种作用,应以邻近推导中的定义为准。

This is the population transform in the source. [S1, p. 2]

这就是原始材料中的群体概率变换。[S1,第2页]

For example, with p1=0.01p_1=0.01,

例如,当 p1=0.01p_1=0.01 时,

P≥1(1)=0.01,P_{\ge1}^{(1)}=0.01,
2.2 From one droplet to many droplets / 从单个液滴到液滴群体; P_ge1: at least one true event

The diagram locates the physical system; its key lists the symbols in the formula. Read the definition in the surrounding derivation when a letter has different roles.

图示标出物理体系,图例列出公式中的符号。若某字母有多种作用,应以邻近推导中的定义为准。

but

而

P≥1(100)=1−0.99100≈0.634.P_{\ge1}^{(100)}=1-0.99^{100}\approx0.634.
2.2 From one droplet to many droplets / 从单个液滴到液滴群体; P_ge1: at least one true event

The diagram locates the physical system; its key lists the symbols in the formula. Read the definition in the surrounding derivation when a letter has different roles.

图示标出物理体系,图例列出公式中的符号。若某字母有多种作用,应以邻近推导中的定义为准。

The individual-droplet probability has not changed, yet the probability of observing at least one event has risen from 1%1\% to approximately 63%63\%. Consequently, an apparent experimental onset can shift simply because the number of available droplets changes.

单个液滴的概率并没有改变,但观察到至少一次事件的概率却从 1%1\% 上升到了约 63%63\%。因此,仅仅改变可参与激活的液滴数量,就可能使实验中的表观起始点发生变化。

The inverse relation follows immediately:

其反演关系可以直接得到:

1−P≥1(N)=(1−p1)N,1-P_{\ge1}^{(N)}=(1-p_1)^N,
2.2 From one droplet to many droplets / 从单个液滴到液滴群体; P_ge1: at least one true event; N: event count / membrane tension; p_1: single-droplet true-event probability

The diagram locates the physical system; its key lists the symbols in the formula. Read the definition in the surrounding derivation when a letter has different roles.

图示标出物理体系,图例列出公式中的符号。若某字母有多种作用,应以邻近推导中的定义为准。

so

因此

p1=1−(1−P≥1(N))1/N.\boxed{p_1=1-\left(1-P_{\ge1}^{(N)}\right)^{1/N}}.
2.2 From one droplet to many droplets / 从单个液滴到液滴群体; p_1: single-droplet true-event probability; P_ge1: at least one true event; N: event count / membrane tension

The diagram locates the physical system; its key lists the symbols in the formula. Read the definition in the surrounding derivation when a letter has different roles.

图示标出物理体系,图例列出公式中的符号。若某字母有多种作用,应以邻近推导中的定义为准。

This inversion depends on the assumed known count and independent, equal-probability event model.

这一反演依赖于以下假设:液滴数量已知,各事件相互独立,且具有相同的发生概率。

2.3 Adding the detector

加入探测器模型

Now let qdq_d be the probability that a real single-droplet event is detected, and fdf_d the false-event probability per observation.

现在,令 qdq_d 表示真实单液滴事件被探测到的概率,fdf_d 表示每次观测出现假事件的概率。

For one droplet,

对于一个液滴,

P(detected real event)=qdp1.P(\text{detected real event})=q_dp_1.
2.3 Adding the detector / 加入探测器模型; P: event probability; q_d: single-event detection efficiency; p_1: single-droplet true-event probability

The diagram locates the physical system; its key lists the symbols in the formula. Read the definition in the surrounding derivation when a letter has different roles.

图示标出物理体系,图例列出公式中的符号。若某字母有多种作用,应以邻近推导中的定义为准。

The probability that none of the droplets produces a detected real event is

没有任何液滴产生被探测到的真实事件,其概率为

(1−qdp1)N.(1-q_dp_1)^N.
2.3 Adding the detector / 加入探测器模型; q_d: single-event detection efficiency; p_1: single-droplet true-event probability; N: event count / membrane tension

The diagram locates the physical system; its key lists the symbols in the formula. Read the definition in the surrounding derivation when a letter has different roles.

图示标出物理体系,图例列出公式中的符号。若某字母有多种作用,应以邻近推导中的定义为准。

Under the source’s independent false-event model, observing no event also requires no false event:

在原始材料采用的独立假事件模型下,未记录到事件还要求没有假事件发生:

P(no recorded event)=(1−fd)(1−qdp1)N.P(\text{no recorded event})=(1-f_d)(1-q_dp_1)^N.
2.3 Adding the detector / 加入探测器模型; P: event probability; f_d: false-detection probability; q_d: single-event detection efficiency; p_1: single-droplet true-event probability; N: event count / membrane tension

The diagram locates the physical system; its key lists the symbols in the formula. Read the definition in the surrounding derivation when a letter has different roles.

图示标出物理体系,图例列出公式中的符号。若某字母有多种作用,应以邻近推导中的定义为准。

Therefore,

因此

Pdet=1−(1−fd)(1−qdp1)N,\boxed{P_{\mathrm{det}}=1-(1-f_d)(1-q_dp_1)^N},
2.3 Adding the detector / 加入探测器模型; P_det: detected-event probability; f_d: false-detection probability; q_d: single-event detection efficiency; p_1: single-droplet true-event probability; N: event count / membrane tension

The diagram locates the physical system; its key lists the symbols in the formula. Read the definition in the surrounding derivation when a letter has different roles.

图示标出物理体系,图例列出公式中的符号。若某字母有多种作用,应以邻近推导中的定义为准。

or equivalently,

等价地,

Pdet=fd+(1−fd)[1−(1−qdp1)N].\boxed{P_{\mathrm{det}}=f_d+(1-f_d)\left[1-(1-q_dp_1)^N\right]}.
2.3 Adding the detector / 加入探测器模型; P_det: detected-event probability; f_d: false-detection probability; q_d: single-event detection efficiency; p_1: single-droplet true-event probability; N: event count / membrane tension

The diagram locates the physical system; its key lists the symbols in the formula. Read the definition in the surrounding derivation when a letter has different roles.

图示标出物理体系,图例列出公式中的符号。若某字母有多种作用,应以邻近推导中的定义为准。

This is why observed onset and underlying event probability are not interchangeable. [S1, p. 2]

这就是为什么观测到的起始点与底层事件概率不能混为一谈。[S1,第2页]

When qd>0q_d>0, fd<1f_d<1, and NN is known, inversion gives

当 qd>0q_d>0、fd<1f_d<1 且 NN 已知时,反演得到

p1=1−(1−Pdet1−fd)1/Nqd.\boxed{p_1=\frac{1-\left(\dfrac{1-P_{\mathrm{det}}}{1-f_d}\right)^{1/N}}{q_d}}.
2.3 Adding the detector / 加入探测器模型; p_1: single-droplet true-event probability; P_det: detected-event probability; f_d: false-detection probability; N: event count / membrane tension; q_d: single-event detection efficiency

The diagram locates the physical system; its key lists the symbols in the formula. Read the definition in the surrounding derivation when a letter has different roles.

图示标出物理体系,图例列出公式中的符号。若某字母有多种作用,应以邻近推导中的定义为准。

The physical bounds 0≤p1≤10\le p_1\le1 imply

由物理取值范围 0≤p1≤10\le p_1\le1 可得

fd≤Pdet≤fd+(1−fd)[1−(1−qd)N].f_d\le P_{\mathrm{det}}\le f_d+(1-f_d)\left[1-(1-q_d)^N\right].
2.3 Adding the detector / 加入探测器模型; f_d: false-detection probability; P_det: detected-event probability; q_d: single-event detection efficiency; N: event count / membrane tension

The diagram locates the physical system; its key lists the symbols in the formula. Read the definition in the surrounding derivation when a letter has different roles.

图示标出物理体系,图例列出公式中的符号。若某字母有多种作用,应以邻近推导中的定义为准。

A measured probability outside those bounds would be inconsistent with the chosen count and detector parameters.

如果测得的概率落在上述范围之外,就说明它与所采用的液滴数量及探测器参数不相容。

The output of Stage 2 is a conditioned event probability—not a universal fluence threshold and not a bubble-radius history. That is the explicit boundary of the second theory page. [S1, p. 2]

阶段2的输出是一个条件事件概率,而不是通用的能量面密度阈值,也不是气泡半径历程。 这正是第二个理论页面明确规定的结论边界。[S1,第2页]

Integrated calculation and model check

综合计算与模型检查

Use the declared parameter set in each part. The values are teaching scenarios unless specifically identified as inherited project inputs. Each reference panel follows its question.

使用每小题明确给出的参数。除明确标为沿用项目输入外,数值均为教学情景。各参考解答紧随题目。

  1. Assume independent identical droplets with p1 = 0.01 and N = 100. Calculate at least one true event. Then take qd = 0.80 and false-detection probability fd = 0.02 and calculate detected-event probability.

    假设独立同分布液滴 p1 = 0.01、N = 100,计算至少一个真实事件的概率。再取 qd = 0.80、误报率 fd = 0.02,计算检测事件概率。

    Reference answer / 参考答案
    P≥1=1−(1−p1)N,Pdet=1−(1−fd)(1−qdp1)NP_{\ge1}=1-(1-p_1)^N,\qquad P_{\mathrm{det}}=1-(1-f_d)(1-q_dp_1)^N
    Activation · original governing laws; P_ge1: at least one true event; p_1: single-droplet true-event probability; N: event count / membrane tension; P_det: detected-event probability; f_d: false-detection probability; q_d: single-event detection efficiency

    The diagram locates the physical system; its key lists the symbols in the formula. Read the definition in the surrounding derivation when a letter has different roles.

    图示标出物理体系,图例列出公式中的符号。若某字母有多种作用,应以邻近推导中的定义为准。

    P≥1 = 0.63397, Pdet = 0.56107. Detection and occurrence are distinct. The binomial population model requires independence and known effective N; bubble interaction or correlated heating may invalidate it.

    P≥1 = 0.63397,Pdet = 0.56107。检测与发生不同。二项群体模型要求独立性和已知有效 N;气泡相互作用或相关加热可能使其失效。

  2. Invert the detected probability above to recover p1, and derive the feasible range of Pdet. What happens if a recorded Pdet is below fd?

    将上述检测概率反演为 p1,推导 Pdet 的可行范围。若记录的 Pdet 低于 fd,会怎样?

    Reference answer / 参考答案
    p1=1−[(1−Pdet)/(1−fd)]1/Nqd,fd≤Pdet≤1−(1−fd)(1−qd)Np_1=\frac{1-[(1-P_{\mathrm{det}})/(1-f_d)]^{1/N}}{q_d},\quad f_d\le P_{\mathrm{det}}\le1-(1-f_d)(1-q_d)^N
    Activation · original governing laws; p_1: single-droplet true-event probability; P_det: detected-event probability; f_d: false-detection probability; N: event count / membrane tension; q_d: single-event detection efficiency

    The diagram locates the physical system; its key lists the symbols in the formula. Read the definition in the surrounding derivation when a letter has different roles.

    图示标出物理体系,图例列出公式中的符号。若某字母有多种作用,应以邻近推导中的定义为准。

    Substitution recovers p1 = 0.0100. A value below fd would yield an inadmissible negative p1 in this ideal model: investigate uncertainty, finite sampling and the detector model. Do not silently clip and call that calibration.

    代入恢复 p1 = 0.0100。低于 fd 会在理想模型中给出不合法负 p1,应调查不确定性、有限采样及探测模型,而非悄悄截断后称作标定。

  3. If peak rate is proportional to dose divided by τL, can unconstrained coefficients on log dose, log rate and log τL all be identified from that dataset? How does energy closure change this?

    若峰值率正比于剂量除以 τL,能从该数据独立辨识 log 剂量、log 峰值率及 log τL 的任意系数吗?能量闭合对此有何影响?

    Reference answer / 参考答案
    ln⁡q˙max⁡′′′=ln⁡Dabs−ln⁡τL+ln⁡4ln⁡2/π\ln\dot q'''_{\max}=\ln D_{\mathrm{abs}}-\ln\tau_L+\ln\sqrt{4\ln2/\pi}
    Activation · original governing laws; q̇'''_max: peak volumetric deposition rate; D_abs: absorbed dose per unit volume; τ_L: laser pulse FWHM; π: circle geometry constant

    The diagram locates the physical system; its key lists the symbols in the formula. Read the definition in the surrounding derivation when a letter has different roles.

    图示标出物理体系,图例列出公式中的符号。若某字母有多种作用,应以邻近推导中的定义为准。

    No: these predictors are algebraically collinear when the pulse family is fixed. Change the experimental design or constrain the parameterization. Energy normalization fixes an input accounting contract; it does not identify statistical activation coefficients.

    不能:脉冲族固定时,这些预测量代数共线。应改变实验设计或约束参数化。能量归一化只确定输入核算约定,不能辨识统计激活系数。

Brief conceptual synthesis

简短概念综合

After using the reference panels, give a short explanation of the physical mechanism, the strongest assumption, and one observation that could falsify this chapter’s model. Preparation of later chapters does not require waiting for that reply.

核对参考解答后,简述物理机制、最强假设,以及一个可证伪本章模型的观测。后续章节编写无需等待该回答。