# Microenvironmental VEGF concentration, not total dose, determines a threshold between normal and aberrant angiogenesis

- Title: Microenvironmental VEGF concentration, not total dose, determines a threshold between normal and aberrant angiogenesis
- Authors: Clare R. Ozawa; Andrea Banfi; Nicole L. Glazer; Gavin Thurston; Matthew L. Springer; Peggy E. Kraft; Donald M. McDonald; Helen M. Blau
- Year: 2004
- DOI: 10.1172/JCI18420
- arXiv ID/URL: Not yet checked
- Source URL: https://doi.org/10.1172/JCI18420
- Record type: journal-article
- Date searched: 2026-10-14
- Record origin: Existing project citation
- Evidence level: Metadata verified; title-based topic summary; experiments unverified
- Access status: Metadata only; full-text access not yet checked.
- Lesson mapping: Background or peripheral citation; placement unreviewed.

## Two-sentence summary

This work addresses Microenvironmental VEGF concentration, not total dose, determines a threshold between normal and aberrant angiogenesis.
Experiments performed remain unverified pending methods or explicit abstract evidence.

## Provenance

Canonical metadata: https://api.crossref.org/works/10.1172%2Fjci18420

Venue: Journal of Clinical Investigation

Local citation locations:

- `reports/Cavitation_Limits_20261011/expert_resolution/sources/literature/PMC10517405.txt:1`

## Applicability and gaps

Project-specific thresholds and transfer performance remain unverified.